Dave Trading – July 2017

*** David Sobek is a disciplined value investor.  Using models, research, and fundamental data, David devises a value for biotech stocks, buys when significantly undervalued, and sells when significantly overvalued.*** As a reminder, this is my personal guide.  You can alter it in accordance with your risk tolerance. >3 Standard deviations – No position 2-3 […]

Dave-Trading June 2017

*** David Sobek is a disciplined value investor.  Using models, research, and fundamental data, David devises a value for biotech stocks, buys when significantly undervalued, and sells when significantly overvalued.*** As a reminder, this is my personal guide.  You can alter it in accordance with your risk tolerance. >3 Standard deviations – No position 2-3 […]

GILD Earnings Trade Idea

Let me preface this by saying that trading earnings is a scary proposition.  Earnings tend to move stocks a lot, particularly when catalysts for the stock tend to be earnings based.  It is also a fool’s game to try to use option pricing as a gauge for how much the stock will move for earnings.  […]

Dave-Trading – May 2017

*** David Sobek is a disciplined value investor.  Using models, research, and fundamental data, David devises a value for biotech stocks, buys when significantly undervalued, and sells when significantly overvalued.*** As a reminder, this is my personal guide.  You can alter it in accordance with your risk tolerance. >3 Standard deviations – No position 2-3 […]

Dave Trading – March 2017

*** David Sobek is a disciplined value investor.  Using models, research, and fundamental data, David devises a value for biotech stocks, buys when significantly undervalued, and sells when significantly overvalued.*** As a reminder, this is my personal guide.  You can alter it in accordance with your risk tolerance. >3 Standard deviations – No position 2-3 […]

December 20 Biotech Update

Well, this has been a strangely interesting day for the week before Christmas. I thought the bulk of news was done but I clearly spoke too soon. There is some good news for the sector as well as some good-well-maybe-bad-let-us-argue news. I am going to go through these as sort of quick hits as none […]

AGIO- Pivot to PKD

Agios Pharmaceuticals came to market in 2013 as a promising cancer metabolism company. Three years later, it has pivoted to rare disease. AG-120, an IDH1 mutant inhibitor being developed for oncology indications, remains the most advanced pipeline compound, but is no longer the main value driver. For that we look to AG-348 and AG-519, mid […]

ASH Update: TGTX

ASH 2016 has turned out to be an important convention for many small biotechs, and will likely be remembered as a break-out event for CAR-T therapies. Results from the Phase 1 TGR-1202/Ibrutinib combination study may prove crucial for the future of TG Therapeutics. Escalating doses of TGR-1202 ranged from 400mg to 800mg with a corresponding 420mg of […]

ASH Update 2: BLCM

Bellicum Pharmaceuticals’ leading clinical candidate is BPX-501, individualized T-cells transduced with a controllable suicide gene. They are being studied for use as an add-back following T-cell depletion during Haploidentical Stem Cell Transplant (HSCT). For individuals with certain hematological disorders, whether malignant or not, stem cell transplants represent the only hope for a cure. Siblings make […]

ASH Update: TRIL

Trillium Therapeutics presented interim data from its ongoing Phase 1 trial of the SIRPaFc TTI-621 at ASH this past weekend. These highly anticipated results gave a deeper look into the molecule’s safety and efficacy profile as well as potential mechanism of action. Trillium is at the forefront of a scramble to target the SIRPa-CD47 checkpoint […]