March 5th Biotech (and Energy) Report

We are in an old fashion sell off.  Have we reached blood in the street/panic bottom yet?  It does not quite feel like that yet but we are so oversold we could have that bounce today.  If not then we are likely looking for a Tuesday reversal as markets generally do not bottom on Fridays.  […]

February 8th Biotech (and MLP) Update

We have moved past the large cap portion of the earnings with positive price action in the sector but less so in the companies that are reporting.  I do not believe that is related to the quality of the earnings as they were generally fine but more of a broader disconnect between large and SMID […]

Cardiol Therapeutics – Pharmaceutical-Grade CBD Entry to the Commercial Market in Canada and a US Phase 2/3 Covid Trial: The Revaluation is Coming

Cardiol Therapeutics (CRTPF) is a Canadian company trading on the Toronto Stock Exchange (the “TSX”) since December 2018 under the symbol CRDL and on the OTCQX under the symbol CRTPF. Cardiol is focused on producing pharmaceutical-grade cannabidiol (CBD) products and developing innovative therapies for heart diseases, targeting acute myocarditis and other causes of heart failure. […]

APLIF – Appili Therapeutics and Avigan, the Antiviral Pill to treat Coronavirus: The Clinical Strategy for EUA

Canada TSX: APLI, US OTCQX: APLIF We previously reported on the need for COVID-19 therapeutics, including in the post-vaccine world, Appili Therapeutics and Avigan the Antiviral Pill to Treat Coronavirus (link here).  Since the publication of that report, daily infections have only continued to rise, and nursing facilities and hospitals are facing an intensified crisis. […]

Perimeter, OTIS – Optical Coherence Tomography and the Future of AI in Surgical Breast Cancer Treatment

Perimeter Medical Imaging AI (PINK.v) is a Toronto-based company with U.S. headquarters in Dallas, Texas developing advanced imaging tools that allow surgeons, radiologists, and pathologists to visualize microscopic tissue structures during cancer excision surgery. Perimeter has an innovative FDA 510(k) approved medical device, soon to launch commercially, that is ready to disrupt breast cancer surgery […]

October 15th Biotech (and MLP) Update

Not much to add as we gear up for earnings season and the sector basically following the broader market in its moves.  It looks like we are switching from setting the new higher high level to establishing the higher low level.  In other words, we are likely in the part of the uptrend where the […]

October 12 Biotech Update

We are not starting the week with new M&A but we are starting the week with strong momentum both with the sector and the broader market.  Of course, very strong broader markets have not necessarily been great in recent weeks for the sector but there is certainly a chance that we break to new highs.  […]

September 24th Biotech Update

We are not quite in trouble with the sector despite the recent sell off and pain.  Obviously the broader market is not helping but we have not broken below recent lows and still can reverse (needs to be soon) higher and make a higher high to start a new trend.  Of course, nothing is guaranteed […]

September 14th Biotech Update

We are back baby!  This is the M&A that the sector has been wanting.  If this cannot break the sector out of the downtrend and push it back to highs (if not higher) then not much else could.  The ideal scenario would be a push above the recent lower high today but we were pretty […]

Cardiol Therapeutics – Pharmaceutical Cannabidiol (CBD) Long-Term Value Creation Will Lead the Way to Acute Myocarditis Clinical Trial

Cardiol Therapeutics (CRTPF) is a Canadian company that completed its initial public offering (IPO) on the Toronto Stock Exchange (the “TSX”) back in December 2018 and trades mainly on the TSX under the symbol CRDL while in the U.S. it trades on the OTCQX under the symbol CRTPF. Cardiol is focused on producing pharmaceutical cannabidiol […]

February 3 Biotech Update

The market is off to a good start this morning but I suspect we fade. The old saying goes that markets never bottom on Fridays and typically when you have a big selloffs on Friday and a bounce Monday morning, the bounce ultimately fades and fails. We will see. We still have some macro that […]

The PTI Bear Case

Proteostasis Therapeutics is a small biotech company focused on the development of treatments for cystic fibrosis. To their credit, they have 3 compounds, each of a different class in the clinic. This is crucial because the current standard of care for CF relies on combination therapy. Vertex laid out a blueprint for CF treatment through […]

Another Look at TPTX

With the entrance of RET inhibitor TPX-0046 into P1/2 last November, fast moving Turning Point Therapeutics now has a full slate of 3 clinical candidates. Soon, another ALK inhibitor is expected to join the fray. Pipeline: The pivotal repotrectinib studies in ROS1 and TRK are ongoing with interim results from some registrational cohorts expected during […]