August 21 Biotech Update

Another slow day on the news front, so this should be another short report. I usually like to begin the reports with a sense of the market but right now it feels like a market looking for direction. There does not seem to be consistent leadership between days and the high growth sectors like biotech […]

August 11 Biotech Update

A relatively mixed early day in the market. The open was modestly positive and biotechs seemed to participate but not dramatically. Again it seemed like it was the small caps that had more of a bid but it was not anything spectacular. The morning seemed dominated by news more than anything else. 1. TKMR is […]

July 30 Biotech Update

The sector and market rallied nicely on the GDP but I am still not convinced that we have an all clear. It was especially disconcerting how quickly the market gave back a lot of the post GDP print gains. Of course, there are still values out there and no reason to sell and run for […]

Update on Protalix

On Wednesday, Protalix (PLX) will present data from their phase I clinical trial of oral glucocerebrosidase (GCD), or Oral GCD (PRX-112), in patients with Gaucher disease. The presentation will be at 1:15pm PST at the Lysosomal Storage Disease Network WORLD Symposium (LDN WORLD). While Sanofi/Genzyme are nearing potential approval of Cerdelga (eliglustat), the data should […]

January 29- Biotech Update

Would you believe another snow day in Louisiana, which is number three in the past couple of weeks (if you were counting). In general, despite a very weak market , biotechs did fairly well, although it was the large caps holding up the sector with the small caps more mixed. It was nice to see […]

November 18-EOD

Thankfully there was not a lot of news but biotechs did not just drift lower. I still worry about tax loss selling hitting the sector (or at least the small to mid caps) heading into the end of the year but it is nice to see that the sector can tread water on no news […]

ASH 2013 Preview on Myelofibrosis

This year’s annual meeting of the American Society of Hematology (ASH13) is highly anticipated for a number of reasons. With the general market for the healthcare/biotech sector at all-time highs on the backs of Pharmacyclic’s Ibrutinib (stock is up 1000% since ASH11), Celgene’s Revlimid (~67% of their $6.3B 2013 revenue) and Amgen’s $10.6B deal for […]

October 16- EOD

With the approach of an end (as temporary as it is likely to be) of the stalemate in Washington you thought we would be approaching the end of the macro driven market. While I think that is likely true, we still are going to have a knee jerk relief rally before it settles back down […]

June 28- EOD

Not much of a lot of new today but there were some interesting tidbits. 1. BIIB spiked higher today on the back of SNY news. The EMA granted Aubagio exclusivity and traders immediately wanted to tie this into the debate over BG12 exclusivity in the EU. I am not sure that this is anything more […]

AEGR – Quick commentary on Aegerion

Aegerion has been one of the best performing stocks over the past 6-12 months. This has been driven by the value creation of Juxtapid (lomitapide), a small molecule microsomal triglyceride transfer protein inhibitor, was approved by the FDA and EMA adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available, in […]

ISIS and AEGR – Where do they stand after the FDA Advisory Committee meetings?

October 17 and 18, 2012 saw back-to-back meetings of the FDA Endocrine and Metabolic Drugs Advisory Committee (EMDAC) to review pending new drug applications (NDAs) for two drugs for homozygous familial hypercholesterolemia (HoFH): lomitapide from Aegerion Pharma (NASDAQ: AEGR) and mipomersen/Kynamro from Sanofi/Genzyme and Isis Pharma (NASDAQ: ISIS). As Chimera predicted, both drugs received positive […]

PFE & BMY – The anticoagulant market & the Apixaban Catalyst

Background: The market for anti-thrombosis agents is set for dramatic changes.  A thrombus is an aggregation of platelets which plays a key part in several life-threatening diseases, such as myocardial infarction, stroke, deep-vein thrombosis, pulmonary embolism, stent thrombosis, as well as other medical conditions. The market for therapies against thrombosis can be broken down simply […]

Sanofi Ditches New R&D Model For Newer Model

When Eias Zerhouni, head of Sanofi’s R&D arrived at the company, he set about changing the company’s large pharma research model to a more “biotech” like one in an attempt to be more creative and nimble. However, Eias has just realized that discovering drugs is more difficult than he had originally thought. No worries- there […]