Is Pharma Over Invested in Antibody Therapeutics?

Jason Chew There is no doubt that antibody therapeutics have revolutionized medicine in the last decades. Sales of antibody drugs are estimated to be $30 billion in 2009 and expected.

Biotech Startups: Begin With an Exit Plan

Jason Chew According to a 2007 study by the Ewing Marion Kauffman Foundation, a nonprofit devoted to entrepreneurship, 40% of youths between the ages of eight and 21 say they.

Crossing the Valley of Death: From Innovation to Cure

The term “Valley of Death” has come to describe the period of transition when a developing technology is deemed promising, but too new to validate its commercial potential and thereby.

Big Pharma: In-licensing is Not the Cure

Jason Chew(Featured in TheBigRedBiotechBlog, digitalpathologyinsights) Historically, the Big Pharma business model has been that of a fully integrated pharmaceutical company, complete with basic research and development, clinical trials, sales and.

First in Class vs. Best in Class- The Economics of Drug Discovery

The genomics and proteomics revolution has produced thousands of new targets for drug discovery. Designing molecules with novel mechanisms is sexy and can be very rewarding but is risky and.

The Virtualization of Drug Development

Virtual Drug Development has been around since the 1990s with little fanfare. In this model, only the key personnel to manage the core operations of a project are retained, while.

Four Emerging Taiwan Drug Developers

Jason Chew Taiwan’s drug makers have largely focused on generics; few are in the business of developing novel medicines. This is partially due to the large resources required for such.

Taiwan Liposome Company- Ahead of the Pack

Jason Chew Biotechnology is an emerging industry in Taiwan. After the country’s immense success in high tech, the government is searching for another engine of economic growth. There are now.

A Rash of Data Expected From Seattle Genetics

Jason Chew(Featured in FieceBiotech, TheBigRedBiotechBlog) This autumn is turning out to be a busy season for Seattle Genetics. The company is expecting results from up to three clinical trials between.

Teva- Evolution of a Generics Company

Jason Chew(Featured on Bullfax) It is difficult to characterize Teva- is it a generics company or a biopharmaceutical? It would appear it is the best of both worlds, a hybrid.

Big Biotech- The End of An Era

Jason Chew In their heyday, big biotech companies rivaled some Big Pharma companies in market capitalization and epitomized innovation in pharmaceutical development. At the time of its acquistion by Roche,.

GSK and Anthera: Novel Treatments for Cardiovascular Disease

Jason Chew The cardiovascular disease (CVD) market is worth approximately $100 billion today and makes up 12% of all global pharmaceutical sales. Unit sales of medicines for CVD are growing,.

A New Era In HCV Drug Development

Jason Chew(Featured in Pegylated interferon plus ribavirin is the current standard of care for HCV treatment. However, it is a 48-week treatment and is only effective in about 50%.

Vivus Investors Flee to Arena Pharmaceuticals

Jason Chew Vivus shares tanked after an expert panel voted 10 to 6 against approving its obesity drug, Qnexa. The panel was particularly worried that Vivus only had one year data.

Gilead: Undervalued

Jason Chew Gilead’s stock has been in a funk. In the last three months, it has dropped 24% from about $46/share to about $35/share, this compares to a 15% drop.

Why Arena’s Lorcaserin Will Not Be Used In Combination With Phentermine

Jason Chew It is tempting to believe that once Lorcaserin has been approved, it will be used off-label in combination with phentermine to create a safe and efficacious version of.

Fail Early, Fail Fast- A Recipe For Failure

Jason Chew The mantra for big Pharma is to fail early and fail fast in preclinical studies, then push compounds out as quickly as possible into first-in-human testing, and gather.

Celgene- On An Acquisition Spree

Jason Chew During the last decade, Celgene has been one of the best performing stocks. With a market cap in the year 2000 of just $2.4 billion, it has grown.

George Scangos Named Biogen Idec’s CEO- Not Entirely a Head Scratcher

Jason Chew June 30, 2010- Geoge Scangos from Exelixis was officially named CEO of Biogen, replacing James Mullen who retired June 8 under pressure from the board. He has biologics.

Calistoga Pharmaceuticals and Plexxikon- Two Biotechs to Keep an Eye On

Jason Chew Calistoga and Plexxikon are on the leading edge of two of the hottest targets in drug development today. Both are privately held. Seattle based Calistoga Pharmaceuticals was founded.

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